ATI Pathophysiology Practice Exam

The release of histamine is primarily associated with which type of cells?

1. Neutrophils

2. Macrophages

3. Mast cells

4. Eosinophils

The correct answer is: Mast cells

The release of histamine is primarily associated with mast cells, which are a type of white blood cell found in connective tissues. When mast cells are activated, often due to an allergic reaction or certain types of immune responses, they degranulate and release histamine into the surrounding tissue. Histamine plays a crucial role in the inflammatory response; it causes vasodilation and increases the permeability of blood vessels, leading to the classic signs of inflammation, such as redness and swelling. This response facilitates the flow of immune cells to the site of an injury or infection. While neutrophils, macrophages, and eosinophils do play significant roles in the immune response, they are not primarily responsible for histamine release. Neutrophils are key players in the innate immune response and primarily target bacterial infections. Macrophages are versatile cells involved in phagocytosis and antigen presentation, and they can release various mediators but are not a major source of histamine. Eosinophils are important in combating parasitic infections and are also involved in allergic reactions but are not the primary cells for histamine release. Thus, mast cells are distinctly recognized for their role in releasing histamine, particularly during allergic responses.